Chemical composition of Propolis Extract ACF® and activity against herpes simplex virus.
Identifieur interne : 002331 ( Main/Exploration ); précédent : 002330; suivant : 002332Chemical composition of Propolis Extract ACF® and activity against herpes simplex virus.
Auteurs : V. Bankova [Bulgarie] ; A S Galabov [Bulgarie] ; D. Antonova [Bulgarie] ; N. Vilhelmova [Bulgarie] ; B. Di Perri [Royaume-Uni]Source :
- Phytomedicine : international journal of phytotherapy and phytopharmacology [ 1618-095X ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Antiviraux (composition chimique), Antiviraux (pharmacologie), Bovins (MeSH), Canada (MeSH), Chromatographie gazeuse-spectrométrie de masse (MeSH), Herpèsvirus humain de type 1 (effets des médicaments et des substances chimiques), Herpèsvirus humain de type 2 (effets des médicaments et des substances chimiques), Lignée cellulaire (MeSH), Onguents (composition chimique), Populus (composition chimique), Propolis (composition chimique), Propolis (pharmacologie).
- MESH :
- composition chimique : Antiviraux, Onguents, Populus, Propolis.
- effets des médicaments et des substances chimiques : Herpèsvirus humain de type 1, Herpèsvirus humain de type 2.
- pharmacologie : Antiviraux, Propolis.
- Animaux, Bovins, Canada, Chromatographie gazeuse-spectrométrie de masse, Lignée cellulaire.
- Wicri :
- geographic : Canada.
English descriptors
- KwdEn :
- Animals (MeSH), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Canada (MeSH), Cattle (MeSH), Cell Line (MeSH), Gas Chromatography-Mass Spectrometry (MeSH), Herpesvirus 1, Human (drug effects), Herpesvirus 2, Human (drug effects), Ointments (chemistry), Populus (chemistry), Propolis (chemistry), Propolis (pharmacology).
- MESH :
- chemical , chemistry : Antiviral Agents, Ointments, Propolis.
- chemical , pharmacology : Antiviral Agents, Propolis.
- geographic : Canada.
- chemistry : Populus.
- drug effects : Herpesvirus 1, Human, Herpesvirus 2, Human.
- Animals, Cattle, Cell Line, Gas Chromatography-Mass Spectrometry.
Abstract
UNLABELLED
Propolis Extract ACF(®) (PPE) is a purified extract manufactured from propolis collected in a Canadian region rich in poplar trees, and it is the active substance of a topical ointment used against herpes labialis (cold sores or fever blisters). Aim of this study was to analyze the chemical composition of PPE in order to understand the plant origin and possible relations between compounds and antiviral activity, and to characterize the antiviral activity of the extract against herpes simplex virus in vitro.
MATERIAL AND METHODS
The analysis of the propolis extract samples was conducted by Gas Chromatography-Mass Spectrometry (GC-MS). The antiviral activity was tested against herpes simplex viruses type 1 and type 2 in MDBK cell cultures by treating the cells with PPE at the time of virus adsorption, and by incubating the virus with the extract before infection (virucidal assay).
RESULTS
Results from the GC-MS analyses revealed a dual plant origin of PPE, with components derived from resins of two different species of poplar. The chemical composition appeared standardized between extract samples and was also reproduced in the sample of topical ointment. The antiviral studies showed that PPE had a pronounced virucidal effect against herpes simplex viruses type 1 and type 2, and also interfered with virus adsorption.
DOI: 10.1016/j.phymed.2014.04.026
PubMed: 25022206
Affiliations:
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Bankova</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria.</nlm:affiliation><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Galabov, A S" sort="Galabov, A S" uniqKey="Galabov A" first="A S" last="Galabov">A S Galabov</name><affiliation wicri:level="3"><nlm:affiliation>Department of Virology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</nlm:affiliation><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Department of Virology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Antonova, D" sort="Antonova, D" uniqKey="Antonova D" first="D" last="Antonova">D. Antonova</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria.</nlm:affiliation><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Vilhelmova, N" sort="Vilhelmova, N" uniqKey="Vilhelmova N" first="N" last="Vilhelmova">N. 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Aim of this study was to analyze the chemical composition of PPE in order to understand the plant origin and possible relations between compounds and antiviral activity, and to characterize the antiviral activity of the extract against herpes simplex virus in vitro.</p></div><div type="abstract" xml:lang="en"><p><b>MATERIAL AND METHODS</b></p><p>The analysis of the propolis extract samples was conducted by Gas Chromatography-Mass Spectrometry (GC-MS). The antiviral activity was tested against herpes simplex viruses type 1 and type 2 in MDBK cell cultures by treating the cells with PPE at the time of virus adsorption, and by incubating the virus with the extract before infection (virucidal assay).</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Results from the GC-MS analyses revealed a dual plant origin of PPE, with components derived from resins of two different species of poplar. The chemical composition appeared standardized between extract samples and was also reproduced in the sample of topical ointment. The antiviral studies showed that PPE had a pronounced virucidal effect against herpes simplex viruses type 1 and type 2, and also interfered with virus adsorption.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25022206</PMID><DateCompleted><Year>2015</Year><Month>03</Month><Day>30</Day></DateCompleted><DateRevised><Year>2014</Year><Month>08</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1618-095X</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>11</Issue><PubDate><Year>2014</Year><Month>Sep</Month><Day>25</Day></PubDate></JournalIssue><Title>Phytomedicine : international journal of phytotherapy and phytopharmacology</Title><ISOAbbreviation>Phytomedicine</ISOAbbreviation></Journal><ArticleTitle>Chemical composition of Propolis Extract ACF® and activity against herpes simplex virus.</ArticleTitle><Pagination><MedlinePgn>1432-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.phymed.2014.04.026</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0944-7113(14)00210-4</ELocationID><Abstract><AbstractText Label="UNLABELLED">Propolis Extract ACF(®) (PPE) is a purified extract manufactured from propolis collected in a Canadian region rich in poplar trees, and it is the active substance of a topical ointment used against herpes labialis (cold sores or fever blisters). Aim of this study was to analyze the chemical composition of PPE in order to understand the plant origin and possible relations between compounds and antiviral activity, and to characterize the antiviral activity of the extract against herpes simplex virus in vitro.</AbstractText><AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">The analysis of the propolis extract samples was conducted by Gas Chromatography-Mass Spectrometry (GC-MS). The antiviral activity was tested against herpes simplex viruses type 1 and type 2 in MDBK cell cultures by treating the cells with PPE at the time of virus adsorption, and by incubating the virus with the extract before infection (virucidal assay).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Results from the GC-MS analyses revealed a dual plant origin of PPE, with components derived from resins of two different species of poplar. The chemical composition appeared standardized between extract samples and was also reproduced in the sample of topical ointment. The antiviral studies showed that PPE had a pronounced virucidal effect against herpes simplex viruses type 1 and type 2, and also interfered with virus adsorption.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier GmbH. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bankova</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galabov</LastName><ForeName>A S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Department of Virology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Antonova</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vilhelmova</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Virology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Di Perri</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Enzpharma (UK) Ltd, Forum House, Stirling Road, PO19 7DN Chichester, United Kingdom. Electronic address: barbara@enzpharma.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>07</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Phytomedicine</MedlineTA><NlmUniqueID>9438794</NlmUniqueID><ISSNLinking>0944-7113</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009824">Ointments</NameOfSubstance></Chemical><Chemical><RegistryNumber>9009-62-5</RegistryNumber><NameOfSubstance UI="D011429">Propolis</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N" Type="Geographic">Canada</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002417" MajorTopicYN="N">Cattle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008401" MajorTopicYN="N">Gas Chromatography-Mass Spectrometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018259" MajorTopicYN="N">Herpesvirus 1, Human</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018258" MajorTopicYN="N">Herpesvirus 2, Human</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009824" MajorTopicYN="N">Ointments</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011429" MajorTopicYN="N">Propolis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antiviral</Keyword><Keyword MajorTopicYN="N">Chromatography</Keyword><Keyword MajorTopicYN="N">Herpes virus</Keyword><Keyword MajorTopicYN="N">Propolis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>12</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>03</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>04</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>7</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>7</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25022206</ArticleId><ArticleId IdType="pii">S0944-7113(14)00210-4</ArticleId><ArticleId IdType="doi">10.1016/j.phymed.2014.04.026</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Bulgarie</li><li>Royaume-Uni</li></country><region><li>Sofia-ville (oblast)</li></region><settlement><li>Sofia</li></settlement></list><tree><country name="Bulgarie"><region name="Sofia-ville (oblast)"><name sortKey="Bankova, V" sort="Bankova, V" uniqKey="Bankova V" first="V" last="Bankova">V. Bankova</name></region><name sortKey="Antonova, D" sort="Antonova, D" uniqKey="Antonova D" first="D" last="Antonova">D. Antonova</name><name sortKey="Galabov, A S" sort="Galabov, A S" uniqKey="Galabov A" first="A S" last="Galabov">A S Galabov</name><name sortKey="Vilhelmova, N" sort="Vilhelmova, N" uniqKey="Vilhelmova N" first="N" last="Vilhelmova">N. Vilhelmova</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Di Perri, B" sort="Di Perri, B" uniqKey="Di Perri B" first="B" last="Di Perri">B. Di Perri</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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